Fibroids trial

Wagman of Myovant Sciences; and Elizabeth A. Stewart of Mayo Clinic. Al-Hendy's clinical and research interests include uterine fibroids, infertility, endometriosis and other reproductive health conditions. We offer online appointment scheduling for video and in-person appointments for adult and pediatric primary care and many specialties.

Skip to content Appointments Close Appointments Schedule your appointment online for primary care and many specialties. Schedule an Appointment Online To request an appointment, please use our secure online form. Request an Appointment Get an online second opinion from one of our experts without having to leave your home. Care Connection Ingalls For help with Ingalls Care Connection, call us at or email portalsupport ingalls.

Share with facebook Share with twitter Share with linkedin. Forefront Women's Health. Study discovers safe, effective oral treatment for uterine fibroids. Call Us At In my opinion, in the United States, we do too many hysterectomies, and I feel our patients with uterine fibroids really deserve to have a wide range of options.

But when they cause significant problems -- such as heavy monthly bleeding and persistent pain -- treatment may be necessary. Traditionally, the go-to has been a hysterectomy, or surgical removal of the uterus.

But women who plan to become pregnant or simply don't want a hysterectomy need other options. One is to have less extensive surgery to remove the fibroids only. The trouble is that the fibroids often return -- especially when there are multiple growths, said Dr.

Shirazian, who was not involved in the new trial, said she is always interested in alternatives for women who do not want surgery or are not good candidates for it. Often, fibroids do not cause symptoms, and generally wane after menopause, since estrogen helps fuel their growth.

But for women who do have symptoms, hysterectomy has all too often been the solution, said Dr. Ayman Al-Hendy, lead researcher on the trial. For their trial, Al-Hendy and his colleagues recruited women from several countries, including the United States. All had heavy menstrual bleeding from fibroids and were randomly assigned to take either the drug combination or a placebo for six months.

The treatment involves a tablet of relugolix, which blocks the activity of a natural hormone known as GnRH. That, in turn, suppresses the ovaries from churning out estrogen and progesterone. We will determine long-term efficacy of RFA Acessa by evaluating the rate of re-treatment for symptomatic fibroids after the RFA Acessa procedure versus myomectomy. Participants will be asked for permission to review their medical records to assess surgical and pregnancy outcomes.

UC San Francisco will have oversight of all scientific and administrative aspects of the study. Uterine Fibroids Fibroids Radiofrequency ablation Myomectomy Leiomyoma Myofibroma Radiofrequency ablation of fibroids Myomectomy of fibroids Women undergoing radiofrequency ablation. Lauren Schiff, MD, associate professor of minimally invasive gynecologic surgery at the school of medicine at the University of North Carolina at Chapel Hill, said that relugolix shapes up as an attractive non-surgical alternative for patients who suffer from fibroids.

As these trials show a safe and effective option to reduce heavy bleeding and pain, the treatment may be ideal for premenopausal patients who do not want to pursue surgery, said Schiff, who was not involved in the study. However, before relugolix could be considered for longer use, Schiff said understanding BMD past the 6-month mark is critical.

Approximately a quarter of those affected by fibroids have symptoms, which often include heavy menstrual bleeding and pain. Injectable long-acting GnRH agonists are effective treatments for uterine fibroids, but are typically not recommended for long-term use because of their hypoestrogenic effects, including BMD loss. For example, Oriahnn, an elagolix combination therapy, is only eligible for use up to two years due to effects on BMD.